RWD48 Inpatient Resource Utilization Outcomes Among Patients Living with Fragile X Syndrome and Comorbid Autism Spectrum Disorder in the US

Fragile X Syndrome (FXS) is the most common heritable cause of autism and intellectual disability. Autism Spectrum Disorder (ASD) characterized by social interaction communication impairment. Individuals with FXS ASD have greater prevalence seizures, persistence sleep problems, increased behavior problems. Examine inpatient resource utilization in FXS-diagnosed patients without ASD. Healthcare Cost Utilization Project Nationwide Inpatient Sample (2016-2019) data were used to assess encounters aged 1+ years old having ICD-10-CM diagnosis FXS. Length stay (LOS), in-hospital mortality cost-to-charge ratio adjusted charges (costs) stratified compared using chi-square t-tests. Sampling-weighted logistic regression analyses estimate impact on while hierarchical models for LOS . The nationally-weighted sample included 6,235 median (IQR) age 20 (11-36) those FXS-ASD 37 (28-59) Admissions more likely be male (85.9% vs 49.7%, p<.0001). Medicaid coverage was among admissions (43.7% 25.4%; p<0.001). FSX-ASD include neurologic neuromuscular chronic conditions (28.1% 15.8%, p<0.001) but less cardiovascular (6.0% 16.3%, p=0.0002). Univariate revealed no statistical differences between (2.0%) (1.8%) After controlling other factors, associated risk (OR=2.33, p=0.0025). Median (3.0 2.5 days) costs ($8,081 6,305) higher however, these not statistically Multivariate showed significant (IRR=1.09, CI=0.96-1.23) or (IRR=1.15, CI=0.99-1.34). Among FSX admissions,